Lithium Synergy combines lithium orotate, known for its ability to help stabilize mood swings related to depression and other mood disorders, with vitamin B12 (methylcobalamin) and trimethylglycine to support healthy methylation pathways. Mood disorders are often due to inositol depletion. Lithium recycles and synthesizes inositol by inhibiting the IMPase enzyme. The phosphoinositol signaling pathway is involved in cell membrane signaling cascades. When salts of lithium are ingested, the lithium ions interact with several neurotransmitters and receptors in the central nervous system, resulting in decreased norepinephrine release and increased serotonin synthesis. Both vitamin B12 in the form of methylcobalamin and trimethylglycine can donate methyl groups to improve methylation; often a weakness in patients with depression and other disorders. Observational studies have found that as many as 30% of patients hospitalized for depression are deficient in vitamin B12. The reasons for the relationship between vitamin B12 deficiency and depression may involve s-adenosylmethionine (SAMe). Vitamin B12 is required for the synthesis of SAMe, a methyl group donor essential for methylation reactions and subsequently the metabolism of neurotransmitters. SAMe deficiency has been related to depression; this hypothesis is supported by several studies that have shown supplementation with SAMe improves depressive symptoms.
Servings Per Container: 120
Suggested Use: As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.
Serving Size: One Capsule
Amount Per Serving:
- Vitamin B-12(as Methylcobalamin)… 250 mcg
- Trimethylglycine (TMG)… 200 mg
- Lithium(as Lithium Orotate)… 5 mg
Other Ingredients: Microcrystalline cellulose, cellulose (capsule), vegetable stearate.
Made with non-GMO ingredients.
Cautions: This product should not be used to replace any anti-depressant medication, including prescription forms of lithium, unless under the direction of a qualified health care practitioner. Lithium should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation or dehydration, or sodium depletion, or by individuals who are taking diuretics or ACE inhibitors. Consult your doctor before use if you are taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic drugs or insulin. Lithium should not be used by pregnant women and breast-feeding mothers. Serum lithium levels should be monitored by a qualified health care provider during use. This product does not contain wheat, yeast, soy, gluten, eggs, corn, dairy, artificial colors, flavors, sugars, or preservatives. Store in a cool, dry place. Keep out of reach of children.If pregnant, nursing, taking other nutritional supplements, or taking medication, consult your healthcare practitioner before use. Keep out of the reach of children. This product was sealed for your protection. Do not use if outer neck/bottle seal is damaged or missing.
Storage: Keep tightly closed in a cool, dry place.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.